منابع مشابه
Of genes and genomes.
Nancy Wexler’s presentation gives a clear impression of what motivates researchers to find out what genes do, especially in humans. I’ll give you the nuts and bolts of how we learn about genes, how we get and interpret information about our genes, and how the requisite technology led to the Human Genome Project. My view (and I think, now, the general view) is that the Project was the only possi...
متن کاملGenes, Genomes and Genomics
Invited Review: Reproducible and target-specific polymerase chain reaction (PCR) amplification relies on several interrelated factors of which primer design is central. Here, we describe new free bioinformatics software, the FastPCR which was developed, and continues to be updated, based on detailed experimental studies of PCR efficiency for the optimal design of primers and probe sequences and...
متن کاملMycobacteriophages: genes and genomes.
Viruses are powerful tools for investigating and manipulating their hosts, but the enormous size and amazing genetic diversity of the bacteriophage population have emerged as something of a surprise. In light of the evident importance of mycobacteria to human health--especially Mycobacterium tuberculosis, which causes tuberculosis--and the difficulties that have plagued their genetic manipulati...
متن کاملOverlapping genes in vertebrate genomes
Overlapping genes in mammalian genomes are unexpected phenomena even though hundreds of pairs of protein coding overlapping genes have been reported so far. Overlapping genes can be divided into different categories based on direction of transcription as well as on sequence segments being shared between overlapping coding regions. The biologic functions of natural antisense transcripts, their i...
متن کاملFinding genes in prokaryotic genomes
Genome sequencing efforts will soon generate hundreds of millions of bases of human genomic DNA containing thousands of novel genes. In the past year, the accuracy of computational gene-finding methods has improved significantly, to the point where a reasonable approximation of the gene structures within an extended genomic region can often be predicted in advance of more detailed experimental ...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 1999
ISSN: 1061-4036,1546-1718
DOI: 10.1038/14254